Cellular and Immunological investigation towards altered host cell responses
We have been working in the field of host cell responses and cellular immunology with special interest of ongoing immune-regulatory responses, cellular function and phenotypes associated to Cell mediated immunity (CMI) of T cells and accessory antigen presenting cells. Currently, we have major interest groups within NISER and also with external collaboration, where we are investigating functional expression of Toll like receptor (TLR) and Transient Receptor Potential Vanilloid (TRPV) Channels in cell mediated immunity (CMI), analyzing cellular and immunological response(s) of host cells during experimental Chikungunya virus (CHIKV) infection along with anti-cancer immunity as major projects. Some of our ongoing research contexts have been briefly depicted below.
Cellular and
Immunological investigations towards Chikungunya Virus (CHIKV) infection
Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and it application. J Virol Methods. 2014 Apr;199:86-94.
Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and it application. J Virol Methods. 2014 Apr;199:86-94.
Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLoS One. June 2014 | Volume 9 | Issue 6 | e100531
In
silico analysis of MHC-I restricted epitopes of
Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8+ T
cell response and advancement of epitope based immunotherapy for CHIKV
infection. Infect Genet Evol. 2015
Apr; 31:118-26.
Study on IronIII(salen) complexes as anti-tumor metallo-drugs
Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol Int. 2014 Oct;38(10):1118-31.
Role of regulatory T cells in cancer immunology
Manipulation of Regulatory T Cells and Antigen Specific CTL-based Tumor Immunotherapy. Immunology 2015 ;144(2):186-96
Functional expression of Transient Receptor Potential channels (TRP), a group of non-selective Ca2+ ion channels, in mammalian cell mediated immunity.
Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Their Implications in Immune Regulation. FEBS Journal 2015
Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Their Implications in Immune Regulation. FEBS Journal 2015
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